Posted by linkadge on October 31, 2004, at 11:43:41
In reply to Cosmetic psychopharmacology giving a damn, posted by lostforwards on October 31, 2004, at 10:58:25
If you take a pure ssri, then it can tend to cause prefrontal hypofunction. Simtulation of the 5-ht2a/c recetptors decreases prefrontal dopaminergic action.
However some of the SSRIs are better in this regard than others. Prozac, blocks the 5-ht2c receptor to a certain degree and actually enhances prefrontal dopamine ouput. If this is taken in combination with zyprexa, a 5-ht2a/c blocker, then there is even more prefrontal dopamine output.
As far as cosmetic pharmacology goes, I don't think we're quite there yet. I find that for the first two months of trying any new drug, it can make subtle changes in my personality. I quicky adapt to these changes and either feel like myself or am still depressed.There are genes that code for serotonin reputake capacity, and in peoples with a bad serotonin/dopamine gene, is where you will find the medications make the most difference.
When a drug makes a person feel "better than well" I would be very cautious. Personally I would think that this is a subtype of bipolar disorder emerging.
The term, "better than well" really makes no sence, cause "well" is really subjective.
But I have tried about 15 different antidepressants and find that after sustained usage, my mood converges to a state of "well"
Linkadge
poster:linkadge
thread:409540
URL: http://www.dr-bob.org/babble/20041029/msgs/409559.html