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Re: Norepinephrine vs. Dopamine » Sad Panda

Posted by sb417 on August 3, 2004, at 0:43:00

In reply to Re: Norepinephrine vs. Dopamine » KaraS, posted by Sad Panda on August 2, 2004, at 23:31:29

> > > You should try some Desipramine to get a feel for an NE increase with less side effects, you can add it to any AD that you are taking. >
> Cheers,> Panda.
>

It is not necessarily true that you can add desipramine to any antidepressant. You shouldn't add it to an MAOI, and if you are particularly sensitive to medication combinations and/or if you have a genetic polymorphism for some of the cytochrome P450 enzymes, especially the 2D6 enzyme, you probably could not add a tricyclic to any antidepressant. Some people have no problem with polypharmacy; others are extremely sensitive to drug combos and can get very sick or die from indiscriminate mixing of medications. It is best that any attempts to mix medications are done under a doctor's supervision.


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