Posted by pablo1 on July 28, 2004, at 13:17:11
In reply to Amisulpride,Mirapex,Requip...?, posted by iris2 on July 27, 2004, at 20:04:49
> [can't remember why]
Amisulpride
Mirapex
Requip
MilnacipranAll but the last are pure dopamine [DA] drugs. Also looked interesting to me because I took wellbutrin (norepenephrine [NE]) and really disliked it. Ritalin & Adderall have a significant NE component also and they seemed to give me an edgy discomfort so I guess I was thinking a stimulant without the NE might help. Or maybe I'm just looking for a good high? It was mentioned here that Adrafinil (as a cheaper substitute for amineptine) combined with amisulpride worked well. Amisulpride is actually an anti-dopamine drug (though it is stimulating) so I don't know if it was some kind of balancing act using the two in small doses. Here's a couple links to that discussion below. The guy has since disappeared from here and was accused of being too experimental with potentially abusable drugs. Frankly I'd go out & get some cocaine if I thought it would help but when I tried some once, it was similar to ritalin & nothing special for me. Cocaine has NE also, not pure dopamine.
http://www.dr-bob.org/babble/20000411/msgs/30535.html
http://www.dr-bob.org/babble/20010714/msgs/70706.htmlThe other end of the spectrum is something like Xyrem which works on GABA. It's terribly expensive and has a very sedative euphoric effect. Neurontin sounds like a milder version of that GABA effect. GABA is what many of the anticonvulsants/mood stabilizers work on. Effexor gave me a nice peaceful antianxiety effect that I associate with the descriptions of some of these though it was limited and the mood dampening wasn't what I wanted. I want to have feelings, it's just the anxiety needs to be turned off. I've tried some of the more sedating opiate type anti-anxiety drugs in the past and was not attracted to them really. Alcohol has an impact on GABA and helps me with that same relaxation so maybe that's another clue that GABA is part of what clicks for me. Nardil is an MAOI that works against GABA for anxiety. Sometimes the opposite effect happens with these things... so strange.
Hmm, if I don't like NE maybe there is a NE buster that would help? I've been looking at this chart I downloaded & searched "NE antagonist" with no results but "DA antagonist" gave the following:
amitriptyline + perphenazine (comorbid depression with (agitation or anxiety)) which sounds like you. That works on a bunch of neurotransmitters though so is pretty messy. loxapine is another one with simple NA antagonism described as an anti-psychotic. mesoridazine, oh, a bunch of antipsychotics... hmm, ever tried those?Well, maybe this helps clear up some of your thoughts on the topic. Good luck with it.
poster:pablo1
thread:371386
URL: http://www.dr-bob.org/babble/20040724/msgs/371670.html