Posted by finelinebob on May 13, 2004, at 23:56:02
In reply to Dopamine and Neopinephrine questionshelp?, posted by morel1 on May 13, 2004, at 19:53:10
> ... now on Celexa 30mg(good for anxiety but does nothing for depression or fatigue- been on 30mg for 2 weeks).
BTW ... 2 weeks is too short a period to evaluate an SSRI. Not that I'm a a big fan of that class of meds, but you've gotta give them more like a month AFAIK...
> I know(i think) that wellbutrin effects dopamine and neopinephrine.http://www.mentalhealth.com/drug/p30-b04.html#Head_2
MentalHealth.com's monograph says it works on all of the Big Three -- seratonin, norepinephrine and dopamine.
> My question is that what are the symtoms of lack of dopamine and/ or neopinephrine.Whatever we do know, seems to me it can't be **enough**. There's no blood test that will map levels of these neurotransmitters to DSM-IV dx's or symptoms. I mean, if there was, then a blood test would tell your doc what meds you need the FIRST time around, and where's the fun in that?!
aCk! 8*b
From what Tony P said, tho, if low levels of norephinephrine has been tagged as something that would cause "physical retardation", then maybe trying a tricyclic would be a better step than switching to wellbutrin. It's basic experimental methodology -- change one variable at a time. If SSRIs aren't doing it for you then you switch to wellbutrin and it works, there are seven possible explanations:
1) wellbutrin affects seratonin differently from the SSRIs you tried, and it works, or
2) it affects norepinephrine in a way that works, or
3) it affects dopamine in a way that works, or
4) it affects seratonin AND norepinephrine in a way that works, or
5) it affects seratonin AND dopamine in a way that works, or
6) it affects norepinephrine AND dopamine in a way that works, or
7) it affects seratonin AND norepinephrine AND dopamine in a way that works.Well, there are some other possiblities as well (ugh! each of these 7 can logically interact with each other), but we'll leave it at that. However, if you switch to a tricyclic and it works, the answer is most likely:
1) it affects norepinephrine in a way that works
and that's pretty much it. If you want to read up a little on possible TCAs, check out this thread:
http://www.dr-bob.org/babble/20040510/msgs/345436.html
hth,
flb
poster:finelinebob
thread:346577
URL: http://www.dr-bob.org/babble/20040510/msgs/346649.html