Posted by Larry Hoover on April 11, 2003, at 16:50:44
In reply to Serious side effect reported, posted by Ed on April 11, 2003, at 13:09:05
> Drugs for mental illness may be causing diabetes............04/11/2003
> US FDA is confronted with evidence that a new generation of
> big-selling drugs such as Zyprexa (Eli Lilly) for Schizophrenia &
> other mental illnesses, cause life threatening diabetes symptoms.
> Wall Street Journal, Anand & Burton
Thanks for the heads-up.I am astounded at both the high incidence and the severity of this dysregulation of glucose associated with olanzapine (and other) atypical antipsychotics.
Just use olanzapine and diabetes in any search engine, or in Medline. Astounding that this has not been better publicized, considering it has been nine months since researchers at Duke published a warning.
Look at the incidence.....near 10%. And ketoacidosis. That's serious.
Schizophr Res 2003 Jan 1;59(1):1-6
New-onset diabetes and ketoacidosis with atypical antipsychotics.Wilson DR, D'Souza L, Sarkar N, Newton M, Hammond C.
Department of Psychiatry, Creighton University School of Medicine, Omaha, NE 68131, USA. [email protected]
Information from the Ohio Department of Mental Health (ODMH) database was reviewed retrospectively to identify patients at the Cincinnati center treated with an atypical antipsychotic and who had also been evaluated or treated for diabetes mellitus. Blood glucose levels, glucose tolerance, or other evaluations of diabetes had been conducted in 14 of the 126 patients treated with atypical antipsychotics. In 11 of the 14, new-onset, acute, and marked glucose intolerance developed after treatment with clozapine, olanzapine or quetiapine. Of these, six patients required insulin therapy (four only transiently) and five patients developed diabetic ketoacidosis (DKA). Also, glucose metabolism was labile in all cases, and was transient in two cases with subsequent resolution despite on-going antipsychotic therapy. Certain atypical antipsychotics may be associated with new-onset glucose intolerance, including acute diabetes and ketoacidosis. Monitoring for changes in blood glucose levels in patients taking atypical antipsychotics may be indicated. More systematic study data are clearly needed.
poster:Larry Hoover
thread:218530
URL: http://www.dr-bob.org/babble/20030411/msgs/218580.html