Re: Cortisol

Posted by Larry Hoover on April 8, 2003, at 11:59:30

In reply to Re: Cortisol , posted by jrbecker on April 8, 2003, at 0:39:06

> A good read that might be a knowledgeable summary for those unfamiliar with this might be:
>
> Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states. PW Gold 1 and GP Chrousos 2. Molecular Psychiatry 2002, Volume 7, Number 3, Pages 254-275
>
> http://psyphz.psych.wisc.edu/front/740%20Class%20Spring%202003/Gold%20%20Organization%20of%20the%20stress%20system.pdf
I can't think of a recent occasion when I have so thoroughly read any paper as I have studied this one. Thank you very much for the link.
Of course, the obvious questions arising from this study amount to :"So what can we do about that?"
What strikes me are the similarities to the theories presented many years ago by Hans Selye. For an exceedingly brief explanation, go to:
http://www.healthnewsnet.com/gap.html
Now, back in the '20s and '30s, when Selye first defined his concepts of stress reactions, there was no way to directly measure the biochemical characteristics of these states. Still, I see the echoes in the current paper. There have been a number of nutritional and herbal "treatments" suggested for the exhaustion phase of chronic stress, based primarily on "softer" science than that presented here, but probably finding increasing validity over years of refinement. It shouldn't take too much trouble to find those ideas.
There is another aspect to the effect of prolonged stress, one that is not even tangentially mentioned in the comprehensive review referenced above: oxidative stress. Dr. Pall has some compelling evidence for the cyclic "locking in" of pathological levels of peroxynitrite as a mediator of the debilitating effects of chronic fatigue, PTSD, and fibromyalgia. It's not a stretch to apply chronic oxidative stress to atypical depression.
Much to think about here. And well worth a re-read.
Lar

Thread

Ok- now who takes vitamins/what kind(s)/how many? Janelle 4/1/03
...
Re: Cortisol and DHEA Balance » Larry Hoover Ron Hill 4/7/03
Re: Cortisol and DHEA Balance » Larry Hoover johnj 4/7/03
Re: Cortisol and DHEA Balance » jrbecker Ron Hill 4/7/03
Re: Cortisol and DHEA Balance Larry Hoover 4/7/03
Re: Cortisol and DHEA Balance » Larry Hoover Ron Hill 4/7/03
Re: Cortisol jrbecker 4/8/03
Re: Cortisol and DHEA Balance Larry Hoover 4/8/03
Re: Cortisol » jrbecker johnj 4/8/03
Re: The Role of Cortisol in Atypical Depression » jrbecker Ron Hill 4/8/03
Re: Cortisol and DHEA Balance » Larry Hoover Pfinstegg 4/8/03
Pls tell me what the DHEA feels like in your brain (nm) » Larry Hoover Ron Hill 4/8/03
Re: DHEA feels like clarity (nm) » Ron Hill Larry Hoover 4/8/03
Re: Cortisol Larry Hoover 4/8/03
Re: Profound clarity or just slight improvement? (nm) » Larry Hoover Ron Hill 4/8/03
Re:Closer to profound than slight. (nm) » Ron Hill Larry Hoover 4/8/03
Re: Interesting. Thanks Lar. (nm) » Larry Hoover Ron Hill 4/8/03
Larry, Ron, jrbecker McPac 4/8/03
thank you everybody....jr, Larry, Ron » Ron Hill johnj 4/8/03
Re: Cortisol Dave1 4/8/03
Re: Cortisol » Dave1 Pfinstegg 4/8/03
Re: double double quotes » McPac Dr. Bob 4/8/03
Important questions regarding hippocampal damage.. Questionmark 4/9/03
Re: Important questions regarding hippocampal damage.. » Questionmark Pfinstegg 4/9/03
Re: DHEA Trial » Larry Hoover Ron Hill 4/9/03
Re: DHEA Trial Larry Hoover 4/9/03
...
Re: Larry, Ron, jrbecker » McPac Cairo 4/14/04

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