Posted by medlib on March 14, 2003, at 22:20:19
In reply to Re: Abilify drug reaction?, posted by SLS on March 14, 2003, at 19:44:25
Hi Scott--
Found this on an ER guide while wandering around the web trying to decide whether to risk an Abilify trial.
- drugs provoking acute akathisia include neuroleptic agents, serotonin receptor antagonists, lithium, levodopa, calcium channel blockers and phenothiazine anti-emetics eg. prochlorperazine or metoclopropamide
- the etiology of akathisia is unknown, but a good response to propanolol suggests a hyperactive adrenergic system- the treatment of acute drug-induced akathisia includes anticholinergic agents (diphenhydramine and benztropine) and propanolol +/- opioids
It goes on to say that anticholinergics aren't helpful for chronic akathisia.
Found the following on a medical mnemonics site; since so many of us are taking or considering taking APs, I thought it might be useful.
Neuroleptic side effects onset
The rule of 4's:
Dystonia: 4 hours-4 days
Akathesia: 4 days-40 days
Extrapyramidal symptoms: 4 days-4 weeks
Tardive dyskinesia: 4 months (greater than)
· Note that tardive is obviously the latest one to happen (tardive=tardy/late).
· Note that the first letters of these four classic symptoms spell "DATE", and this mnemonic is the dates when they occur.Hope that Abilify proves helpful for you.---medlib
poster:medlib
thread:208723
URL: http://www.dr-bob.org/babble/20030314/msgs/209248.html