Posted by Phil on October 2, 2002, at 12:44:42
In reply to Re: Got the Lamictal rash! » Dinah, posted by Sunnely on October 1, 2002, at 19:15:55
I don't think this contradicts Sunnely but in studies regarding epilepsy, SJ Syndrome was seen.
Sounds like odds are slim though. I wonder if antibiotics cause it at a higher rate?PURPOSE: Lamotrigine (LTG) is an antiepileptic drug (AED) recently released in several countries. It is effective for a variety of seizure types in adults and children both as an add-on agent and in monotherapy, and is generally well tolerated. This report reviews the apparent risk factors for rash associated with LTG to determine whether and how the risk of serious rash can be minimized in practice. METHODS: The panel of experts reviewed all published and unpublished data related to the incidence and risk factors for serious rash with LTG.
RESULTS: An allergic skin reaction occurs in approximately 10% of patients, usually in the first 8 weeks. Rashes leading to hospitalization, including Stevens-Johnson syndrome and hypersensitivity syndrome, occurred in approximately one of 300 adults and one of 100 children in clinical trials and appeared to be increased with overrapid titration when starting therapy and with concurrent valproate (VPA).
CONCLUSIONS: Recommendations are made for both minimizing the likelihood of serious rash and for management of rash in patients taking LTG. Risk of serious rash may possibly be lessened by strict adherence to manufacturer's dosing guidelines, particularly in patients who are at higher risk: those on concurrent VPA and in the pediatric population.
poster:Phil
thread:121742
URL: http://www.dr-bob.org/babble/20020930/msgs/121966.html