Posted by mike21 on April 8, 2002, at 19:32:12
In reply to Re: Benzo Preferences anyone??, posted by Elizabeth on April 7, 2002, at 23:06:34
>
> Klonopin is nice and long-acting, which makes it more convenient than most benzos. Valium isn't very long-acting for the reasons I mentioned, even though it's metabolized into nordiazepam, which is very long-lived.
>
Elizabeth,When you say valium isn't long-acting for reasons mentioned, I assume you are referring to the previous post where you said it is rapidly taken up into the CNS then redistributed.
Is nordiazepam just another type of benzo with varying effects for various people? Does it have any specific properties which make it different from other benzos?
You'll recall from a recent post that I have had success with benzos- specifically it has been valium for me. I've tried xanax but for me a benzo has to be long acting, or the fluctuation in blood levels is unpleasant. I am thinking that "if it ain't broke, don't fix it," but I am interested in the number of raves about klonopin on this board. Also, it is maybe 10 times(?) more potent than valium, so I'm thinking over the long haul, it would be a better choice- less for my liver to metabolize.
This next question probably falls under "YMMV" but would you expect valium or klonopin to have a longer therapeutic half-life? I've heard valium is 20-200 hours half-life, which based on your previous statement must include its metabolites. I've heard for a young person this number is probably closer to 24 hours. I've heard klonopin is in the 18-30 hours range. Sounds like for someone with fairly high metabolism their effective half-lives could be pretty close.
Do you have any thoughts?
Mike
poster:mike21
thread:101944
URL: http://www.dr-bob.org/babble/20020408/msgs/102428.html