Posted by 3 Beer Effect on March 18, 2002, at 23:11:09
In reply to d-amphetamine vs. l-amphetamine?, posted by MB on March 18, 2002, at 16:10:17
Adderall is a mix of two amphetamines & two amphetamine salts. So, Adderall is 1/4 Dexedrine (D-amphetamine) & 1/4 Benzedrine (d,l racemic amphetamine). The other two amphetamine salts I am not that familiar with- I believe they have not been marketed by themselves in the last 50 years. Adderall used to be called Obetrol, an old DIET PILL until Shire pharmaceuticals bought it, renamed it, put it through ADD trials & now has captured an ever-increasing share of the ADD market.
Anyways, Benzedrine (d,l racemic amphetamine) was taken off the market long ago because it causes major peripheral stimulation (nervousness) without much CNS stimulation. It is also one of the most famous drugs of abuse of the 1960s. The Benzedrine asthma inhaler had a benzedrine pill in it that people would take out & snort, shoot, or just add it to their morning coffee. So it was taken off the market.
Dexedrine is far superior to Benzedrine since it causes 5 times as much CNS brain stimulation without as much peripheral stimulation as d,l amphetamine. This is because it contains only the good isomer, the d-isomer of amphetamine.
I do not know in which order the four different amphetamines of Adderall kick in. Adderall is designed to last 6 hours. But it sounds like you might benefit from a longer acting stimulant rather than a short acting one- as long as blood levels of amphetamine are rising, you experience a positive effect, but once they start coming down dysphoria usually sets in.
Keep in mind that Vitamin A, & anything acidic like fruit juices or cola increases the excretion, reduces absorptions & lessens the effects of any amphetamine. So it is best to drink water. Anything that reduces stomach acid or that increases the alkalinity of your stomach increases the absorption of amphetamines & lessens urinary excretion thus prolonging its duration of action. Baking Soda, which is very alkaline, is the best agent for this purpose- On the side of the Arm & Hammer box is a recipe for Baking Soda antacid. If you take this with your amphetamine you will notice a huge difference.
Ritalin, Focalin, Concerta- all forms of methyphenidate do NOT cause as much peripheral stimulation as Adderall or Dexedrine. (20 mg of Ritalin= 10 mg of Dexedrine). Methylphenidate is primarily a pretty selective brain stimulant with fewer peripheral & less prominent anorexic effects. But I noticed Ritalin makes you shy & introverted while Dexedrine & Adderall make you confident & outgoing. Concerta & Ritalin are good for ADD but not for mood (or as an anti-depressant).
If I were you I would ask for Dexedrine Spansules (available in 5, 10 or 15 mg dosages) or Adderall XR. Keep in mind, in order to maintain effaciousness, that when switching to a long acting amphetamine the dose is usually increased by atleast 20% of your daily dose of IR Dexedrine or Adderall. Because Dexedrine Spansules last 11 hours you have to be sure to get a high enough dose to be effective. (I think the peak effects are at eight hours post dose). The good thing about the Dexedrine spansules is that you only have to take your total daily dose once a day (in the morning). Dexedrine used to be called the "basic antidepressant" back in the 1950s. Either of these would probably be an improvement since there is less of a comedown & hence less dysphoria- I would recommend the Dexedrine Spansules because they cause more brain stimulation & less nervousness/peripheral stimulation than Adderall or Adderall XR. Spansule technology is an old technology, so I don't know how well it works, so I would ask for the highest dose you could and then titrate it down if its too high. Spansules supposed to release an effective dose immediately and the rest is released in 4? stages throughout the day. I myself am hoping to get rid of the 200 mg Provigil I am taking, which is a glorified $5 a pill version of extended release caffeine & switch to Dexedrine Spansules.
There is immediate release Dexedrine but it is only available in 5 mg tablets. Dexedrine lasts almost as long as Adderall (4.5 to 6+ hours) but you will still have the same come-down/rebound crappy feeling. Dextrostat is the exact same thing (d-amphetamine) except its cheaper & they offer both 5 & 10 mg tablets.
The only other choice would be Desoxyn (Abbott laboratories) which lasts for a long time- it is the pharmaceutical grade methamphetamine hcl. Unlike the street version, Desoxyn is a clean safe version & is sometimes prescribed for children with ADD. It is (much) more expensive & only comes in 5 mg tablets, but I believe it lasts atleast 8 hours. Most doctors won't prescribe it because of its generic name.
poster:3 Beer Effect
thread:98610
URL: http://www.dr-bob.org/babble/20020318/msgs/98712.html