Posted by Mb on July 24, 2001, at 11:39:28
In reply to Re: Marijuana Use MB, posted by JohnL on July 23, 2001, at 3:38:19
> Back to Zyprexa, I have come to believe that low doses of Zyprexa, Risperdal, or Amisulpride actually increase dopamine activity, while higher doses decrease it. I have no facts on this, but all the anecdotal evidence seems to point in that direction.
> JohnThis is an interesting theory! I think the atypical neuroleptics like Zyprexa actually block certain serotonin receptors...a subclass of receptors that has a dopamine inhibitory effect. So...blocking the receptors increases dopamine levels in certain parts of the brain. So, if you were to take one of these drugs in an amount that blocked these serotonin receptors (5HT-2C are they?) but *didn't* block dopamine receptors, you could possibly get a dopamine *enhancing* effect. This, I think would only work if the drug had a higher affinity for the serotonin receptor than the dopamine receptor. Does anybody have quantitative data to corroborate of refute this idea? It's an interesting possibility, but I'm only guessing at this point (a dangerous thing when I get started < g >).
poster:Mb
thread:70842
URL: http://www.dr-bob.org/babble/20010720/msgs/71631.html