Posted by MB on July 21, 2001, at 19:15:23
In reply to Re: Marijuana Use, posted by JohnL on July 21, 2001, at 9:25:42
> > I must add a personal point, just to voice my thoughts. pot 4 me was not a depressant, It made me a little sleepy to start, but by the end I was not anything but happy and amused.(I used to have a fairly bad habit 4 about 10 months). In fact pot may have precipitated a '?hypomanic?' phase. Possibly if pot was legal in the UK (as it will be in a few years) then I would be self medicating as its the only 'antidepressant' that has made any difference.
>
> One of the main things marijuana does is increase dopamine activity. So if you respond well to marijuana, then that could be a hint that dopamine drugs such as Zyprexa, Risperdal, or Amisulpride might work well.
But doesn't marijuana increase dopaminergic activity, while Zyprexa decreases it?
> Marijuana is tricky because if you smoke too regularly you can build tolerance to it. And then when you back off you will experience a severe, though short, depressive fall. When that dopamine level drops, look out below.
> John
Or, as I've had happen before, when the tolorance builds, the depressive fall can hit even *while* you're smoking...you're smoking the marijuana, but it's not doing anything, and you fall into a depression. During the last stages of my pot smoking career, the first session of the day wold work wonders...then it would wear off, depression would return, and no matter how much more I smoked that day, it wouldn't help. I'd have to wait until the next day for that first hit of the day. It was really frustrating!!
poster:MB
thread:70842
URL: http://www.dr-bob.org/babble/20010720/msgs/71244.html