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Re: Topomax and Wellbutrin vs Menstrual cycle » kmh

Posted by SalArmy4me on June 5, 2001, at 22:17:22

In reply to Topomax and Wellbutrin vs Menstrual cycle, posted by kmh on June 5, 2001, at 21:43:11

There is some evidence that suggests that Topiramate has an effect on the reproductive system, more specifically on the efficacy of orally-contraception pills (OCPs): "However, many anticonvulsant medications can induce an increase in hepatic microsomal enzymes, which can produce increased pill metabolism: "The result has been a decrease in the pill’s contraceptive efficacy resulting in an estimated 3.1 pregnancies per 100 women years of use. These medications include carbamazepine, topiramate, and tiagabine. A number of anticonvulsants do not cause such interference, including valproic acid and lamotrigine."
Greydanus, Donald E. MD et al. Contraception in the Adolescent: An Update. Pediatrics. 107(3):562-573, March 2001.

I don't know what this means clinically.


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