Posted by anita on August 7, 2000, at 17:32:18
In reply to Re: Soical detachment: Anita, posted by AndrewB on August 7, 2000, at 10:23:26
Hi Andrew,
I am glad to have gotten over that episode, but I still fear it coming back, since I still have some bad days like that.
I've actually been on Lamictal for 3 years. When I've upped my dose, I get zombielike and unemotional.
I have a new theory about dopamine & my irritability side-effect: I wonder if the irritability is caused by the increased noradrenaline that is synthesized from dopamine. Perhaps adding something like clonidine to a dopaminergic med might help... I'm going to look at the differences between the norep and dopamine pathways in the brain today. Any thoughts?
I'm glad the selegiline is helping you. I haven't really considered it because of the short half-life of its amphetamine-like metabolite -- I'm very sensitive to that, getting terrible "downs" --- which is what happened with Parnate & Ritalin. BTW, I have a friend who takes selegiline recreationally (2.5-5mg), and he loves it.
anita
> Anita,
>
> I'm sorry you had to go through such hell recently. Īt must be such a relief that the Lamictal is helping. I hope you can build on this recent success.
>
> I wonder, since you are taking a mood stabilizer, you will respond differently now to dopaminergics. Or maybe you will have to add on yet another mood stabilizer first.
>
> By the way, Akiskal is the editor of the book, The Spectrum of Chronic Depressions.
>
> I'm now on the dopaminergics selegiline (low dose, just 5mg./day) and amisulpride. I'm in the process of trialing some arousal agents now. But really I feel very good now. I guess it is the selegiline. It is subtle, taking over a month to work, but it seems to really enhance the amisulpride. The effects of amisulpride don't tend to wilt under stress anymore. My social anxiety seems to actually be in the normal range now. I'm actually enjoying conversations and such so much. You know, just freely laughing a lot. I remember when I'd look at people laughing and talking and wonder what planet they were on (or what planet I was on!).
>
> Best wishes,
>
> AndrewB
poster:anita
thread:42160
URL: http://www.dr-bob.org/babble/20000729/msgs/42341.html