Posted by Adam on May 31, 2000, at 13:29:14
In reply to Early 1960s OCD Tx with LSD, posted by Cam W. on May 27, 2000, at 0:01:54
I believe it was the LSD connection that helped provide clues directing researchers to the 5-HT2A/5-HT2C receptors and their role in the anti-obsessional effects of serotonergics, along with mCPP, since many of the hallicinogens like LSD and psilocybin are potent agonists at these receptors
It has been my understanding, though, that relief from obsessions was observed so long as the patient was intoxicated with these drugs. I have also read that mCPP can cause psychedelic-like effects, such as the persistance of images after the visual stimulus is removed, along with its other troubling accute effects on anxiety.
I just wonder how the therapeutic benefits of the current potent 5-HT2-receptor agonists for OCD could be balanced with their other effects, since they seem to be either anxiogenic and/or induce mental states similar to psychosis. Pre-treatment with serotonin antagonist seems to attenuate the negative effects of mCPP, but is this a good solution for psychedelics? Would chronic treatment with, say, a certain dose of psilocybin, lead to a reduction in hallucinogenic potential as well as retention of anti-obsessional efficacy?
I guess I have some doubts about this approach. It seems to me that such therapies would only be of use to those very severly afflicted by OCD and refractory to all other forms of pharmacological treatment. Even then, given the choice between perpetual intoxication with a hallucinogen or the negative effects of surgical interventions for OCD, surgery might be superior.
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> James - While researching a paper I was writing about LSD I had read a few case studies using LSD and psychotherapy successfully in reducing OCD in several people. The LSD was used during talk therapy to gain insight into their disorder. These studies were done just a few years before LSD became a restricted drug. The psilocybin may be used in a similar manner. The results should be interesting. It is nice to see that some of the prejudice toward hallucinogens is beginning to dissipate. I believe that these drugs, if used properly in a clinical setting with a qualified therapist, may help with various psychiatric conditions (eg OCD, substance abuse, certain personality disorders, etc.). Thanks for the info James. - Cam
poster:Adam
thread:34799
URL: http://www.dr-bob.org/babble/20000526/msgs/35384.html