Posted by SLS on May 22, 2000, at 14:15:53
In reply to Re: Rather not die alone (Risperidone), posted by PeterJ on May 22, 2000, at 0:43:42
> > Does Risperidone result in weight gain as a function of appetite? or does it cause some metabolic change?
> Risperidone can cause weight gain by both mechanisms. Risperidone blocks histamine, serotonin and dopamine receptors. This results in an increase in appetite, which is difficult to control. There is also some metabolic effect due to the increase in the hormone prolactin which may occur. The metabolic effect is probably relatively small at the dose you are taking, but it can be a factor.
By what metabolic mechanisms do neuroleptics cause weight-gain?
> The effects of risperidone may, to some extent, be counteracted, by diet and exercise, but it isn't easy. The appetite-increasing effect of the drug tells your body it needs more food, and it is hard to work against this.
Is leptin involved in this?
> Weight lifting (in addition to cardio) may be helpful as at least some of the added weight may be muscle instead of fat.
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Weight-lifting can help to reduce body fat (not simply shunt calories to muscle through anabolism) in three ways:1. Testosterone is secreted in response to the intensity of the exercise.
2. Growth-hormone (GH) is secreted during moderate to intense exercise.
* Question for PeterJ: Do neuroleptics inhibit the release of exercise-induced GH secretion?
Both of these hormones are lipolytic - they promote the burning of fat. In addition, these hormones act synergistically to promote an increase in whole body metabolism.
3. The release of adrenalin and norepinephrine during exercise directly stimulates adipose tissue to burn of fat.
Very often, a person who is bodybuilding can reduce his percentage of body fat down to %10 without jogging a single mile. This fat loss is not attributable simply to the number of calories burned from the exercise itself.
The basal metabolism rate (BMR) is increased. (Sometimes the term "resting metabolism rate" - RMR is used). You begin to burn more calories per hour, even while you are sitting on your butt doing nothing.
"Cardiovascular" or aerobic exercise - increasing your heart-rate to between 60 - 85 percent of your maximum (220 minus your age) for twenty minutes or more - will also promote an increase in growth-hormone release and BMR. However, to simply burn calories, walking does the trick very nicely. Weight-lifting and walking make a good combination. Jogging, a high-impact exercise, can ruin knees and ankles.
It is recommended that for maximum fat burning, exercise be performed at a moderate level (60%) for a more extended period of time, for example: walking for forty minutes versus running for twenty minutes.
Circuit-training is counterproductive.
- Scott
poster:SLS
thread:32301
URL: http://www.dr-bob.org/babble/20000517/msgs/34304.html