Posted by Scott L. Schofield on February 29, 2000, at 17:24:58
In reply to Re: Reboxetine - Nobody loves me any more., posted by AndrewB on February 29, 2000, at 16:04:12
> I've read that an MAOI may be combined with reboxetine and that the combo may eliminate the need for dietary restrictions.
Adam,
Thanks again for the info. The fact that this combination has been tried before without calamity is very, VERY exciting. I can't wait!
Thanks again for the info. Oh, I said that already.
Quite a few years ago, one of my doctors mentioned that tricyclics, desipramine (Norpramine) in particular, could provide a "buffer" against the "cheese-reaction". My guess is that the physiology behind this involves the dilation of peripheral blood-vessels. I don't know. Last I read, the mechanism(s) responsible for this reaction were not well understood. That both reboxetine and desipramine are rather potent and selective norepinephrine (NE) reuptake inhibitors may explain the association of both of these drugs with a reduced potential for a tyramine-induced hypertensive crisis.
At this point, I feel that the key word here is "reduced". Unless there are reliable studies and sufficient statistics demonstrating that dietary restrictions can indeed be eliminated, I wouldn't want to test the hypothesis.
I would like to point out that moclobemide (Mannerix), a reversible MAO-inhibitor that is selective for MAO type-A, is not supposed to have a need of dietary restrictions, nor a contraindication of combining it with an SSRI. If you do a quick search on Medline, you will see anecdotal reports indicating otherwise.
Thanks again for the info.
- Scott
poster:Scott L. Schofield
thread:24263
URL: http://www.dr-bob.org/babble/20000220/msgs/24952.html